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3W2O

EGFR Kinase domain T790M/L858R Mutant with TAK-285

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AEpidermal growth factor receptorpolymer33138021.01UniProt (P00533)
Pfam (PF07714)
In PDB
Homo sapiens (human)Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
2AN-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamidenon-polymer548.01Chemie (03P)
3waterwater18.037Chemie (HOH)
Sequence modifications
A: 698 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
His 692-expression tag
His 693-expression tag
His 694-expression tag
His 695-expression tag
His 696-expression tag
His 697-expression tag
Met 790Thr 790engineered mutation
Arg 858Leu 858engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight38021.0
Non-Polymers*Number of molecules1
Total formula weight548.0
All*Total formula weight38568.9
*Water molecules are not included.

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PDB entries from 2024-04-24

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