3V92

S663A Stable-5-LOX

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Arachidonate 5-lipoxygenase	polymer	691	79420.2	2	UniProt (P09917) Pfam (PF01477) Pfam (PF00305) In PDB	Homo sapiens (human)	5-LO, 5-lipoxygenase
2	B, A	FE (II) ION	non-polymer		55.8	2	Chemie (FE2)
3		water	water		18.0	161	Chemie (HOH)

Sequence modifications

B, A: 3 - 673 (UniProt: P09917)

PDB	External Database	Details
Met -17	-	expression tag
Gly -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
Gly -5	-	expression tag
Leu -4	-	expression tag
Val -3	-	expression tag
Pro -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag
His 2	-	expression tag
Glu 16	Trp 14	engineered mutation
His 17	Phe 15	engineered mutation
Gly 43	Asn 44	SEE REMARK 999
Ser 44	Asp 45	SEE REMARK 999
Gly 75	Trp 76	engineered mutation
Ser 76	Leu 77	engineered mutation
Ala 240	Cys 241	engineered mutation
Ala 561	Cys 562	engineered mutation
Glu 653	Lys 654	engineered mutation
Asn 654	Lys 655	engineered mutation
Leu 655	Lys 656	engineered mutation
Ala 663	Ser 664	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	158840.5
Non-Polymers*	Number of molecules	2
	Total formula weight	111.7
All*	Total formula weight	158952.2

*Water molecules are not included.