3UFF

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cdelta

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Protein kinase C delta type	polymer	65	7314.5	2	UniProt (P28867) Pfam (PF00130) In PDB	Mus musculus (mouse)	nPKC-delta
2	A, B	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	A, B	PHOSPHATE ION	non-polymer		95.0	6	Chemie (PO4)
4		water	water		18.0	239	Chemie (HOH)

Sequence modifications

A, B: 231 - 280 (UniProt: P28867)

PDB	External Database	Details
Gly 222	-	expression tag
Ser 223	-	expression tag
Arg 224	-	expression tag
Arg 225	-	expression tag
Ala 226	-	expression tag
Ser 227	-	expression tag
Val 228	-	expression tag
Gly 229	-	expression tag
Ser 230	-	expression tag
Thr 236	Tyr 236	engineered mutation
Glu 281	-	expression tag
Phe 282	-	expression tag
Ile 283	-	expression tag
Val 284	-	expression tag
Thr 285	-	expression tag
Asp 286	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	14629.0
Non-Polymers*	Number of molecules	10
	Total formula weight	831.5
All*	Total formula weight	15460.4

*Water molecules are not included.