3U88
Crystal structure of human menin in complex with MLL1 and LEDGF
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Menin | polymer | 550 | 61061.2 | 2 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
| 2 | M, N | Histone-lysine N-methyltransferase 2A | polymer | 75 | 7782.7 | 2 | UniProt (Q03164) In PDB | Homo sapiens (Human) | Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX |
| 3 | C, D | Lens epithelium-derived growth factor | polymer | 89 | 10346.1 | 2 | UniProt (O75475) Pfam (PF11467) In PDB | Homo sapiens (Human) | CLL-associated antigen KW-7,Dense fine speckles 70 kDa protein,DFS 70,Transcriptional coactivator p75/p52 |
| 4 | A, B | CHOLIC ACID | non-polymer | 408.6 | 2 | Chemie (CHD) | |||
| 5 | A, B, C | L-CANAVANINE | non-polymer | 176.2 | 5 | Chemie (GGB) | |||
| 6 | A, B | (4beta,8alpha,9R)-6'-methoxy-10,11-dihydrocinchonan-9-ol | non-polymer | 326.4 | 2 | Chemie (0BR) | |||
| 7 | D, A, B, C | GLYOXYLIC ACID | non-polymer | 74.0 | 6 | Chemie (GLV) | |||
| 8 | N, A, B, M | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) |
Sequence modifications
A, B: 2 - 459 (UniProt: O00255)
A, B: 520 - 610 (UniProt: O00255)
M, N: 36 - 153 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
M, N: 36 - 153 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 5 | - | expression tag |
| Arg 6 | - | expression tag |
| Trp 7 | - | expression tag |
| Arg 8 | - | expression tag |
| Phe 9 | - | expression tag |
| Pro 10 | - | expression tag |
| Ala 11 | - | expression tag |
| Arg 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Gly 14 | - | expression tag |
| Thr 15 | - | expression tag |
| Gly 23 | - | expression tag |
| Arg 24 | - | expression tag |
| Arg 25 | - | expression tag |
| Gly 26 | - | expression tag |
| Leu 27 | - | expression tag |
| Gly 28 | - | expression tag |
| Gly 29 | - | expression tag |
| Ala 30 | - | expression tag |
| Pro 31 | - | expression tag |
| Arg 32 | - | expression tag |
| Gln 33 | - | expression tag |
| Arg 34 | - | expression tag |
| Val 35 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 158380.1 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 3563.6 | |
| All* | Total formula weight | 161943.7 |
