3TKS

Crystal structure of full-length human peroxiredoxin 4 in three different redox states

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Peroxiredoxin-4	polymer	246	28027.6	2	UniProt (Q13162) Pfam (PF00578) Pfam (PF10417) In PDB	Homo sapiens (human)	Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372
2	C, D	Peroxiredoxin-4	polymer	246	28043.6	2	UniProt (Q13162) Pfam (PF00578) Pfam (PF10417) In PDB	Homo sapiens (human)	Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372
3	E	Peroxiredoxin-4	polymer	246	28011.6	1	UniProt (Q13162) Pfam (PF00578) Pfam (PF10417) In PDB	Homo sapiens (human)	Antioxidant enzyme AOE372, AOE37-2, Peroxiredoxin IV, Prx-IV, Thioredoxin peroxidase AO372, Thioredoxin-dependent peroxide reductase A0372
4	A, C, D	PEROXIDE ION	non-polymer		32.0	3	Chemie (PER)
5		water	water		18.0	475	Chemie (HOH)

Sequence modifications

A, B: 1 - 234 (UniProt: Q13162)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

C, D: 1 - 234 (UniProt: Q13162)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

E: 1 - 234 (UniProt: Q13162)

PDB	External Database	Details
Met -11	-	expression tag
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	140154.0
Non-Polymers*	Number of molecules	3
	Total formula weight	96.0
All*	Total formula weight	140250.0

*Water molecules are not included.