3THB
Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Serine/threonine-protein kinase PLK1 | polymer | 333 | 37480.6 | 1 | UniProt (P53350) Pfam (PF00069) In PDB | Homo sapiens (human) | Polo-like kinase 1, PLK-1, Serine/threonine-protein kinase 13, STPK13 |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylpyridin-3-yl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thi one | non-polymer | 453.0 | 1 | Chemie (3TA) |
Sequence modifications
A: 13 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Val 210 | Thr 210 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37480.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 518.4 | |
| All* | Total formula weight | 37999.0 |
