3RN5

Structural basis of cytosolic DNA recognition by innate immune receptors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Interferon-inducible protein AIM2	polymer	208	23480.5	4	UniProt (O14862) Pfam (PF02760) In PDB	Homo sapiens (human)	Absent in melanoma 2
2	K, M	DNA (5'-D(*CP*CP*AP*TP*CP*AP*AP*AP*GP*AP*GP*AP*GP*AP*AP*AP*GP*AP*G)-3')	polymer	19	5904.9	2
3	L, N	DNA (5'-D(*GP*CP*TP*CP*TP*TP*TP*CP*TP*CP*TP*CP*TP*TP*TP*GP*AP*TP*G)-3')	polymer	19	5743.7	2
4	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
5		water	water		18.0	163	Chemie (HOH)

Sequence modifications

A, B, C, D: 144 - 343 (UniProt: O14862)

PDB	External Database	Details
Gly 140	-	expression tag
Ser 141	-	expression tag
Val 142	-	expression tag
Asp 143	-	expression tag
Ala 344	-	expression tag
Ala 345	-	expression tag
Ala 346	-	expression tag
Ser 347	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	117219.0
Non-Polymers*	Number of molecules	9
	Total formula weight	558.6
All*	Total formula weight	117777.6

*Water molecules are not included.