3QOX

DOT1L structure in complex with SAH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Histone-lysine N-methyltransferase	polymer	426	48697.4	1	UniProt (Q8TEK3) Pfam (PF08123) In PDB	Homo sapiens (human)	DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4
2	A	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)
3	A	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4		water	water		18.0	102	Chemie (HOH)

Sequence modifications

A: 1 - 416 (UniProt: Q8TEK3)

PDB	External Database	Details
Met -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	48697.4
Non-Polymers*	Number of molecules	5
	Total formula weight	768.7
All*	Total formula weight	49466.1

*Water molecules are not included.