3QEM

Crystal structure of amino terminal domains of the NMDA receptor subunit GluN1 and GluN2B in complex with Ro 25-6981

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	NMDA glutamate receptor subunit	polymer	383	42932.1	2	UniProt (Q91977) Pfam (PF01094) UniProt (by SIFTS) (A0A1L8F5J9) In PDB	Xenopus laevis (African clawed frog)
2	B, D	Glutamate [NMDA] receptor subunit epsilon-2	polymer	364	41367.9	2	UniProt (Q00960) Pfam (PF01094) In PDB	Rattus norvegicus (rat)	N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B
3	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
5	A, C	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6	B, D	4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol	non-polymer		339.5	2	Chemie (QEM)

Sequence modifications

A, C: 23 - 405 (UniProt: Q91977)

PDB	External Database	Details
Gln 61	Asn 61	engineered mutation
Gln 371	Asn 371	engineered mutation

B, D: 31 - 394 (UniProt: Q00960)

PDB	External Database	Details
Asp 348	Asn 348	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	168599.9
Branched	Number of molecules	1
	Total formula weight	910.8
Non-Polymers*	Number of molecules	9
	Total formula weight	1831.0
All*	Total formula weight	171341.7

*Water molecules are not included.