3P0G
Structure of a nanobody-stabilized active state of the beta2 adrenoceptor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-2 adrenergic receptor, Lysozyme | polymer | 501 | 56716.5 | 1 | UniProt (P07550) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB | Homo sapiens (human Bacteriophage T4) | Endolysin, Lysis protein, Muramidase |
2 | B | Camelid Antibody Fragment | polymer | 126 | 13784.2 | 1 | LAMA GLAMA | ||
3 | A | 8-[(1R)-2-{[1,1-dimethyl-2-(2-methylphenyl)ethyl]amino}-1-hydroxyethyl]-5-hydroxy-2H-1,4-benzoxazin-3(4H)-one | non-polymer | 370.4 | 1 | Chemie (P0G) |
Sequence modifications
A: 1 - 227 (UniProt: P07550)
A: 227 - 233 (UniProt: P00720)
A: 233 - 365 (UniProt: P07550)
B: 1 - 120 (PDB: 3P0G)
PDB | External Database | Details |
---|---|---|
Asp -7 | - | expression tag |
Tyr -6 | - | expression tag |
Lys -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Ala 0 | - | expression tag |
Arg 16 | Gly 16 | SEE REMARK 999 |
Gln 27 | Glu 27 | SEE REMARK 999 |
Glu 187 | Asn 187 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Thr 229 | Cys 54 | conflict |
Ala 230 | Cys 97 | conflict |
B: 1 - 120 (PDB: 3P0G)
PDB | External Database | Details |
---|---|---|
His 121 | - | expression tag |
His 122 | - | expression tag |
His 123 | - | expression tag |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 70500.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 370.4 | |
All* | Total formula weight | 70871.1 |