Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3OHF

Crystal structure of beta-site app-cleaving enzyme 1 (BACE-WT) complex with bms-655295 aka n~3~-((1s,2r)-1- benzyl-2-hydroxy-3-((3-methoxybenzyl)amino)propyl)-n~1~, n~1~-dibutyl-1h-indole-1,3-dicarboxamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BBeta-secretase 1polymer45550220.52UniProt (P56817)
Pfam (PF00026)
In PDB
Homo sapiens (human)Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, Asp 2, ASP2
2A, BN~3~-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-N~1~,N~1~-dibutyl-1H-indole-1,3-dicarboxamidenon-polymer598.82Chemie (3HF)
3A, BIODIDE IONnon-polymer126.92Chemie (IOD)
4A, BGLYCEROLnon-polymer92.12Chemie (GOL)
5waterwater18.0802Chemie (HOH)
Sequence modifications
A, B: 1 - 441 (UniProt: P56817)
PDBExternal DatabaseDetails
Met -13-EXPRESSION TAG
Ala -12-EXPRESSION TAG
Ser -11-EXPRESSION TAG
Met -10-EXPRESSION TAG
Thr -9-EXPRESSION TAG
Gly -8-EXPRESSION TAG
Gly -7-EXPRESSION TAG
Gln -6-EXPRESSION TAG
Gln -5-EXPRESSION TAG
Met -4-EXPRESSION TAG
Gly -3-EXPRESSION TAG
Arg -2-EXPRESSION TAG
Gly -1-EXPRESSION TAG
Ser 0-EXPRESSION TAG
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight100441.0
Non-Polymers*Number of molecules6
Total formula weight1635.5
All*Total formula weight102076.5
*Water molecules are not included.

221051

PDB entries from 2024-06-12

PDB statisticsPDBj update infoContact PDBjnumon