3N7P
Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, J | Calcitonin gene-related peptide type 1 receptor | polymer | 115 | 13572.4 | 4 | UniProt (Q16602) Pfam (PF02793) In PDB | Homo sapiens (human) | CGRP type 1 receptor, Calcitonin receptor-like receptor |
2 | D, E, F, R | Receptor activity-modifying protein 1 | polymer | 96 | 11002.5 | 4 | UniProt (O60894) Pfam (PF04901) In PDB | Homo sapiens (human) | Calcitonin-receptor-like receptor activity-modifying protein 1, CRLR activity-modifying protein 1 |
3 | A, B, D, E, J... | SULFATE ION | non-polymer | 96.1 | 16 | Chemie (SO4) | |||
4 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A, B, C, J: 23 - 133 (UniProt: Q16602)
D, E, F, R: 26 - 117 (UniProt: O60894)
PDB | External Database | Details |
---|---|---|
Gly 19 | - | EXPRESSION TAG |
Ser 20 | - | EXPRESSION TAG |
His 21 | - | EXPRESSION TAG |
Met 22 | - | EXPRESSION TAG |
PDB | External Database | Details |
---|---|---|
Gly 22 | - | EXPRESSION TAG |
Ser 23 | - | EXPRESSION TAG |
His 24 | - | EXPRESSION TAG |
Met 25 | - | EXPRESSION TAG |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 98299.5 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 1537.0 | |
All* | Total formula weight | 99836.5 |