3LAU

Crystal Structure of Aurora2 kinase in complex with a GSK3beta inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase 6	polymer	287	33342.2	1	UniProt (O14965) Pfam (PF00069) In PDB	Homo sapiens (human)	Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase
2	A	N-[6-(4-hydroxyphenyl)-1H-indazol-3-yl]butanamide	non-polymer		295.3	1	Chemie (OFI)
3		water	water		18.0	92	Chemie (HOH)

Sequence modifications

A: 125 - 399 (UniProt: O14965)

PDB	External Database	Details
Met 124	-	expression tag
Asp 288	Thr 288	engineered mutation
Ala 400	-	expression tag
Ala 401	-	expression tag
Ala 402	-	expression tag
Leu 403	-	expression tag
Glu 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33342.2
Non-Polymers*	Number of molecules	1
	Total formula weight	295.3
All*	Total formula weight	33637.5

*Water molecules are not included.