3KVW

Crystal Structure of dual-specificity tyrosine phosphorylation regulated kinase 2 (DYRK2) in complex with an indirubin ligand

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Dual specificity tyrosine-phosphorylation-regulated kinase 2	polymer	429	49600.9	1	UniProt (Q92630) Pfam (PF00069) In PDB	Homo sapiens (human)	DYRK2
2	A	(2Z,3E)-7'-bromo-3-(hydroxyimino)-2'-oxo-1,1',2',3-tetrahydro-2,3'-biindole-5-carboxylic acid	non-polymer		400.2	1	Chemie (IRB)
3	A	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4		water	water		18.0	107	Chemie (HOH)

Sequence modifications

A: 73 - 479 (UniProt: Q92630)

PDB	External Database	Details
Met -21	-	initiating methionine
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Sep -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	49600.9
Non-Polymers*	Number of molecules	5
	Total formula weight	542.0
All*	Total formula weight	50142.9

*Water molecules are not included.