3KDF

X-ray Crystal Structure of the Human Replication Protein A Complex from Wheat Germ Cell Free Expression

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Replication protein A 14 kDa subunit	polymer	121	13774.1	2	UniProt (P35244) Pfam (PF08661) In PDB	Homo sapiens (human)	RP-A p14, Replication factor A protein 3, RF-A protein 3
2	D, B	Replication protein A 32 kDa subunit	polymer	132	14982.4	2	UniProt (P15927) In PDB	Homo sapiens (human)	RP-A p32, RP-A p34, Replication factor A protein 2, RF-A protein 2
3	A, D, C	1,2-ETHANEDIOL	non-polymer		62.1	7	Chemie (EDO)
4		water	water		18.0	258	Chemie (HOH)

Sequence modifications

A, C: 1 - 121 (UniProt: P35244)

PDB	External Database	Details
Ser 1	Met 1	engineered mutation

D, B: 41 - 172 (UniProt: P15927)

PDB	External Database	Details
Ser 41	Ala 41	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57513.0
Non-Polymers*	Number of molecules	7
	Total formula weight	434.5
All*	Total formula weight	57947.5

*Water molecules are not included.