3ETB
Crystal structure of the engineered neutralizing antibody M18 complexed with anthrax protective antigen domain 4
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | F, G, H, I | Antibody M18 light chain and antibody M18 heavy chain linked with a synthetic (GGGGS)4 linker | polymer | 252 | 26866.6 | 4 | Mus musculus (mouse) | ||
2 | J, K, L, M | Anthrax Protective Antigen | polymer | 144 | 16499.6 | 4 | UniProt (P13423) Pfam (PF20835) In PDB | Bacillus anthracis | PA, PA-83, PA83, Anthrax toxins translocating protein [Contains: Protective antigen PA-20 and Protective antigen PA-63] |
Sequence modifications
F, G, H, I: 1 - 108 (PDB: 3ETB)
F, G, H, I: 1001 - 1113 (PDB: 3ETB)
PDB | External Database | Details |
---|---|---|
Met -4 | - | expression tag |
Ala -3 | - | expression tag |
Asp -2 | - | expression tag |
Tyr -1 | - | expression tag |
Lys 0 | - | expression tag |
Val 21 | Ile 21 | engineered mutation |
Phe 46 | Leu 46 | engineered mutation |
Pro 56 | Ser 56 | engineered mutation |
Asn 76 | Ser 76 | engineered mutation |
Leu 78 | Gln 78 | engineered mutation |
Pro 94 | Leu 94 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 109 | - | linker |
Gly 110 | - | linker |
Gly 111 | - | linker |
Gly 112 | - | linker |
Ser 113 | - | linker |
Gly 114 | - | linker |
Gly 115 | - | linker |
Gly 116 | - | linker |
Gly 117 | - | linker |
Ser 118 | - | linker |
Gly 119 | - | linker |
Gly 120 | - | linker |
Gly 121 | - | linker |
Gly 122 | - | linker |
Ser 123 | - | linker |
Gly 124 | - | linker |
Gly 125 | - | linker |
Gly 126 | - | linker |
Gly 127 | - | linker |
Ser 128 | - | linker |
Asn 1030 | Ser 30 | engineered mutation |
Ser 1057 | Thr 58 | engineered mutation |
Glu 1064 | Lys 65 | engineered mutation |
Ile 1068 | Thr 69 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 173464.7 | |
All* | Total formula weight | 173464.7 |