3EFW
Structure of AuroraA with pyridyl-pyrimidine urea inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase 6 | polymer | 267 | 31036.7 | 2 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase |
| 2 | A, B | 1-[3-methyl-4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)phenyl]-3-[3-(trifluoromethyl)phenyl]urea | non-polymer | 494.5 | 2 | Chemie (AK8) | |||
| 3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62073.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1181.1 | |
| All* | Total formula weight | 63254.5 |
