3COH
Crystal structure of Aurora-A in complex with a pentacyclic inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Serine/threonine-protein kinase 6 | polymer | 268 | 31007.7 | 2 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora kinase A, Aurora-A, Serine/threonine kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase |
| 2 | A, B | 8-ethyl-3,10,10-trimethyl-4,5,6,8,10,12-hexahydropyrazolo[4',3':6,7]cyclohepta[1,2-b]pyrrolo[2,3-f]indol-9(1H)-one | non-polymer | 348.4 | 2 | Chemie (83H) |
Sequence modifications
A, B: 124 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 124 | Lys 124 | engineered mutation |
| Asn 154 | Gln 154 | engineered mutation |
| Ser 203 | Ala 203 | engineered mutation |
| Lys 251 | Arg 251 | engineered mutation |
| Ala 287 | Thr 287 | engineered mutation |
| Ala 288 | Thr 288 | engineered mutation |
| Asp 336 | Glu 336 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62015.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 696.9 | |
| All* | Total formula weight | 62712.2 |
