3C4M

Structure of human parathyroid hormone in complex with the extracellular domain of its G-protein-coupled receptor (PTH1R)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor	polymer	539	60297.9	2	UniProt (P0AEX9) UniProt (Q03431) Pfam (PF01547) Pfam (PF02793) In PDB	Escherichia coli ( human)	Maltodextrin-binding protein, MMBP, PTH/PTHr receptor, PTH/PTHrP type I receptor
2	C, D	Parathyroid hormone	polymer	21	2546.0	2	UniProt (P01270) In PDB		Parathyrin, PTH, Parathormone
3	E, F	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
4		water	water		18.0	580	Chemie (HOH)

Sequence modifications

A, B: -344 - 22 (UniProt: P0AEX9)

PDB	External Database	Details
Met -345	-	initiating methionine
Asn 23	-	linker
Ala 24	-	linker
Ala 25	-	linker
Ala 26	-	linker
Glu 27	-	linker
Phe 28	-	linker
His 188	-	expression tag
His 189	-	expression tag
His 190	-	expression tag
His 191	-	expression tag
His 192	-	expression tag
His 193	-	expression tag

A, B: 29 - 187 (UniProt: Q03431)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	125687.8
Branched	Number of molecules	2
	Total formula weight	684.6
All*	Total formula weight	126372.4

*Water molecules are not included.