3BBR

Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Glutamate receptor 2	polymer	263	29194.7	2	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Rattus norvegicus (rat)	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, AMPA-selective glutamate receptor 2
2	A, B	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	A, B	GLUTAMIC ACID	non-polymer		147.1	2	Chemie (GLU)
5	A	N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide	non-polymer		424.6	1	Chemie (BHY)
6	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7		water	water		18.0	524	Chemie (HOH)

Sequence modifications

A, B: 3 - 117 (UniProt: P19491)

PDB	External Database	Details
Gly 1	-	expression tag
Ala 2	-	expression tag

A, B: 120 - 263 (UniProt: P19491)

PDB	External Database	Details
Gly 118	-	SEE REMARK 999
Thr 119	-	SEE REMARK 999
Ser 242	Asn 775	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58389.3
Non-Polymers*	Number of molecules	11
	Total formula weight	1418.8
All*	Total formula weight	59808.1

*Water molecules are not included.