3B2U
Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J, M... (L, D, G, K, O...) | IMC-11F8 Fab Light chain | polymer | 213 | 23053.6 | 8 | Homo sapiens (human) | ||
| 2 | B, E, H, K, N... (H, C, F, J, N...) | IMC-11F8 Fab Heavy chain | polymer | 223 | 23604.4 | 8 | Pfam (PF07686) Pfam (PF07654) UniProt (by SIFTS) (Q6GMX6) | Homo sapiens (human) | |
| 3 | C, F, I, L, O... (A, B, E, I, M...) | Epidermal growth factor receptor | polymer | 214 | 23786.1 | 8 | UniProt (P00533) Pfam (PF01030) | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 4 | CA, EA, Y (c, e, Y) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 5 | BA, DA, GA, LA, NA... (b, d, g, l, n...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 6 | AA, FA, IA, JA, KA... (a, f, i, j, k...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 7 | In PDB GlyTouCan (G15407YE) | |||
| 7 | HA (h) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G78750JU) | |||
| 8 | AB, CB, DB, EB, GB... (I, M, P, S, V...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 14 | Chemie (NAG) | |||
| 9 | BB, FB, IB, LB, SA... (O, U, X, V, A...) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 10 | AC, BC, CC, DC, EC... (M, R, Q, P, U...) | water | water | 18.0 | 1036 | Chemie (HOH) |
Sequence modifications
A, B, E, I, M, P, S, V: 311 - 514 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Leu 307 | - | expression tag |
| Glu 308 | - | expression tag |
| Glu 309 | - | expression tag |
| Lys 310 | - | expression tag |
| His 515 | - | expression tag |
| His 516 | - | expression tag |
| His 517 | - | expression tag |
| His 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 24 |
| Total formula weight | 563552.2 | |
| Branched | Number of molecules | 18 |
| Total formula weight | 10233.5 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3865.4 | |
| All* | Total formula weight | 577651.1 |
