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3B2U

Crystal structure of isolated domain III of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8

Summary for 3B2U
Entry DOI10.2210/pdb3b2u/pdb
Related3B2V
DescriptorIMC-11F8 Fab Light chain, IMC-11F8 Fab Heavy chain, Epidermal growth factor receptor, ... (10 entities in total)
Functional Keywordscell surface receptor; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug, anti-oncogene, atp-binding, cell cycle, disease mutation, kinase, membrane, nucleotide-binding, phosphoprotein, secreted, transferase, transmembrane, tyrosine-protein kinase, immune system-transferase complex, immune system/transferase
Biological sourceHomo sapiens (human)
More
Total number of polymer chains24
Total formula weight577651.09
Authors
Ferguson, K.M.,Li, S.,Kussie, P. (deposition date: 2007-10-19, release date: 2008-02-19, Last modification date: 2023-08-30)
Primary citationLi, S.,Kussie, P.,Ferguson, K.M.
Structural basis for EGF receptor inhibition by the therapeutic antibody IMC-11F8.
Structure, 16:216-227, 2008
Cited by
PubMed: 18275813
DOI: 10.1016/j.str.2007.11.009
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.58 Å)
Structure validation

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