2YLA
INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | BETA-N-ACETYLHEXOSAMINIDASE | polymer | 442 | 49632.8 | 4 | UniProt (P49610) Pfam (PF00728) | STREPTOCOCCUS PNEUMONIAE | GLYCOSIDE HYDROLASE GH20 |
| 2 | E, F, H (E, F, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 951.9 | 3 | In PDB GlyTouCan (G62723TD) | |||
| 3 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G13201UL) | |||
| 4 | I, J, K, L, M... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 5 | AA, X, Y, Z (D, A, B, C) | water | water | 18.0 | 772 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 627 - 1064 (UniProt: P49610)
| PDB | External Database | Details |
|---|---|---|
| Gly 623 | - | expression tag |
| Ser 624 | - | expression tag |
| His 625 | - | expression tag |
| Met 626 | - | expression tag |
| Gln 805 | Glu 805 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 198531.0 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3604.3 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 931.0 | |
| All* | Total formula weight | 203066.3 |
