2YL8
Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | BETA-N-ACETYLHEXOSAMINIDASE | polymer | 434 | 48206.8 | 1 | UniProt (P49610) Pfam (PF00728) In PDB | STREPTOCOCCUS PNEUMONIAE | GLYCOSIDE HYDROLASE GH20 |
| 2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G85856KC) | |||
| 3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 9 | Chemie (MN) | |||
| 4 | A | POLYETHYLENE GLYCOL (N=34) | non-polymer | 1529.8 | 2 | Chemie (15P) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | water | water | 18.0 | 623 | Chemie (HOH) |
Sequence modifications
A: 181 - 614 (UniProt: P49610)
| PDB | External Database | Details |
|---|---|---|
| Gln 361 | Glu 361 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48206.8 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 383.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3616.2 | |
| All* | Total formula weight | 52206.3 |
