2WJ1

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	FATTY-ACID AMIDE HYDROLASE 1	polymer	573	63111.7	2	UniProt (P97612) Pfam (PF01425) In PDB	RATTUS NORVEGICUS (RAT)	OLEAMIDE HYDROLASE 1, ANANDAMIDE AMIDOHYDROLASE 1, FATTY ACID AMIDE HYDROLASE
2	A, B	7-phenyl-1-(4-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol	non-polymer		352.4	2	Chemie (S99)
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4		water	water		18.0	625	Chemie (HOH)

Sequence modifications

A, B: 7 - 29 (PDB: 2WJ1)
A, B: 30 - 579 (UniProt: P97612)

PDB	External Database	Details
Phe 192	Leu 192	engineered mutation
Tyr 194	Phe 194	engineered mutation
Thr 377	Ala 377	engineered mutation
Asn 435	Ser 435	engineered mutation
Val 491	Ile 491	engineered mutation
Met 495	Val 495	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	126223.3
Non-Polymers*	Number of molecules	3
	Total formula weight	740.3
All*	Total formula weight	126963.6

*Water molecules are not included.