2WCX

Crystal Structure of Hepatitis C Virus NS5B Polymerase in Complex with Thienopyrrole-Based Finger-Loop Inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-DIRECTED RNA POLYMERASE	polymer	537	59772.7	1	UniProt (P26663) Pfam (PF00998) In PDB	HEPATITIS C VIRUS	HEPATITIS C VIRUS RNA-DEPENDENT-RNA-POLYMERASE, NS5B, P68
2	A	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
3	A	6-CYCLOHEXYL-4-METHYL-5-PHENYL-4H-THIENO[3,2-B]PYRROLE-2-CARBOXYLIC ACID	non-polymer		339.5	1	Chemie (VGC)
4		water	water		18.0	507	Chemie (HOH)

Sequence modifications

A: 0 - 0 (PDB: 2WCX)
A: 1 - 536 (UniProt: P26663)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	59772.7
Non-Polymers*	Number of molecules	3
	Total formula weight	449.3
All*	Total formula weight	60222.0

*Water molecules are not included.