2RKG
HIV-1 PR resistant mutant + LPV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PROTEASE RETROPEPSIN | polymer | 100 | 10912.8 | 2 | UniProt (A0F7J4) Pfam (PF00077) UniProt (by SIFTS) (A0F6C5) In PDB | human immunodeficiency virus 1 (HIV-1) | HIV-1 PROTEASE |
| 2 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 3 | B | N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE | non-polymer | 628.8 | 1 | Chemie (AB1) | |||
| 4 | water | water | 18.0 | 145 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 100 (UniProt: A0F7J4)
| PDB | External Database | Details |
|---|---|---|
| Val 13 | Ile 13 | engineered mutation |
| Ala 16 | Gly 16 | engineered mutation |
| Met 20 | Lys 20 | engineered mutation |
| Glu 34 | - | insertion |
| Ser 38 | Asn 37 | engineered mutation |
| Val 47 | Ile 46 | engineered mutation |
| Met 55 | Leu 54 | engineered mutation |
| Leu 64 | Pro 63 | engineered mutation |
| Ile 94 | Leu 93 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21825.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 813.0 | |
| All* | Total formula weight | 22638.5 |
