2QS4
Crystal structure of the GluR5 ligand binding core dimer in complex with LY466195 at 1.58 Angstroms resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Glutamate receptor, ionotropic kainate 1 | polymer | 258 | 29211.5 | 4 | UniProt (P22756) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (rat) | Glutamate receptor 5, GluR-5, GluR5 |
| 2 | A, D | AMMONIUM ION | non-polymer | 18.0 | 2 | Chemie (NH4) | |||
| 3 | A, B, C, D | (3S,4aR,6S,8aR)-6-{[(2S)-2-carboxy-4,4-difluoropyrrolidin-1-yl]methyl}decahydroisoquinoline-3-carboxylic acid | non-polymer | 346.4 | 4 | Chemie (LY5) | |||
| 4 | B, C | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 1148 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 3 - 116 (UniProt: P22756)
A, B, C, D: 119 - 258 (UniProt: P22756)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 117 | - | linker |
| Thr 118 | - | linker |
| Ser 258 | Glu 821 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 116846.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1605.7 | |
| All* | Total formula weight | 118451.9 |
