2Q7N
Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Leukemia inhibitory factor receptor | polymer | 488 | 55018.0 | 2 | UniProt (P42703) Pfam (PF18207) Pfam (PF17971) Pfam (PF21177) Pfam (PF00041) In PDB | Mus musculus (house mouse) | LIF receptor, LIF-R, D-factor/LIF receptor, CD118 antigen |
| 2 | B, D | Leukemia inhibitory factor | polymer | 180 | 19739.9 | 2 | UniProt (P15018) Pfam (PF01291) In PDB | Homo sapiens (human) | LIF, Differentiation-stimulating factor, D factor, Melanoma-derived LPL inhibitor, MLPLI, Emfilermin |
| 3 | E, H, I, N, O | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 5 | In PDB GlyTouCan (G21290RB) | |||
| 4 | F, G, L, M, P... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 5 | J | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G48068RF) | |||
| 6 | K | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G47477HI) | |||
| 7 | R | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G26032DN) | |||
| 8 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A, C: 7 - 486 (UniProt: P42703)
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | - | cloning artifact |
| Tyr 0 | - | cloning artifact |
| Lys 1 | - | cloning artifact |
| Asp 2 | - | cloning artifact |
| Asp 3 | - | cloning artifact |
| Asp 4 | - | cloning artifact |
| Asp 5 | - | cloning artifact |
| Lys 6 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149515.8 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 8199.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 158379.1 |
