2P2C

Inhibition of caspase-2 by a designed ankyrin repeat protein (DARPin)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	Caspase-2	polymer	169	19006.6	6	UniProt (P42575) Pfam (PF00656) In PDB	Homo sapiens (human)
2	B, D, F, H, J...	Caspase-2	polymer	106	12052.2	6	UniProt (P42575) Pfam (PF00656) In PDB	Homo sapiens (human)
3	P, Q, R, S, T...	Caspase-2	polymer	169	18444.6	6		Homo sapiens (human)
4		water	water		18.0	29	Chemie (HOH)

Sequence modifications

A, C, E, G, I, K: 2 - 168 (UniProt: P42575)

PDB	External Database	Details
Met 0	-	cloning artifact
Ala 1	-	cloning artifact
Leu 7	Val 172	variant

B, D, F, H, J, L: 201 - 305 (UniProt: P42575)

PDB	External Database	Details
Met 200	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	18
	Total formula weight	297019.8
All*	Total formula weight	297019.8

*Water molecules are not included.