2OI4
Crystal structure of human PIM1 in complex with fluorinated ruthenium pyridocarbazole
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Proto-oncogene serine/threonine-protein kinase Pim-1 | polymer | 313 | 35632.6 | 1 | UniProt (P11309) Pfam (PF00069) In PDB | Homo sapiens (human) | |
| 2 | X | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | X | FLUORINATED PYRIDOCARBAZOLE CYCLOPENTADIENYL RU(CO) COMPLEX | non-polymer | 498.4 | 1 | Chemie (JM1) | |||
| 4 | X | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | X | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 6 | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
X: 1 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Gly 250 | Arg 341 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35632.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 958.4 | |
| All* | Total formula weight | 36591.0 |
