2IK8
Crystal structure of the heterodimeric complex of human RGS16 and activated Gi alpha 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | Guanine nucleotide-binding protein G(i), alpha-1 subunit | polymer | 324 | 37102.3 | 2 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B, D | Regulator of G-protein signaling 16 | polymer | 140 | 15917.9 | 2 | UniProt (O15492) Pfam (PF00615) In PDB | Homo sapiens (human) | RGS16, Retinally abundant regulator of G-protein signaling, RGS-R, A28-RGS14P |
| 3 | A, C | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
| 4 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 6 | A, C | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 7 | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
B, D: 53 - 190 (UniProt: O15492)
| PDB | External Database | Details |
|---|---|---|
| Ser 51 | - | cloning artifact |
| Met 52 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 106040.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1909.5 | |
| All* | Total formula weight | 107949.8 |
