2ID4
The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Kexin | polymer | 503 | 55180.8 | 2 | UniProt (P13134) Pfam (PF00082) Pfam (PF01483) In PDB | Saccharomyces cerevisiae (baker's yeast) | KEX2 protease, Proteinase YSCF |
| 2 | C, D | Ac-RERK-CMK inhibitor | polymer | 6 | 650.2 | 2 | BIRD (PRD_000246) | ||
| 3 | E, F | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G07375KG) | |||
| 4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 5 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | A, B | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | A | MALONIC ACID | non-polymer | 104.1 | 1 | Chemie (MLA) | |||
| 8 | water | water | 18.0 | 711 | Chemie (HOH) |
Sequence modifications
A, B: 114 - 613 (UniProt: P13134)
| PDB | External Database | Details |
|---|---|---|
| Arg 614 | - | expression tag |
| Gln 615 | - | expression tag |
| Arg 616 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 111661.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 752.8 | |
| All* | Total formula weight | 113263.5 |
