2GHM
Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-activated protein kinase 14 | polymer | 348 | 39854.6 | 1 | UniProt (P47811) Pfam (PF00069) In PDB | Mus musculus (house mouse) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, CRK1 |
| 2 | A | 3-(2-CHLOROBENZYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA | non-polymer | 470.0 | 1 | Chemie (LIC) | |||
| 3 | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
A: 5 - 352 (UniProt: P47811)
| PDB | External Database | Details |
|---|---|---|
| Ala 180 | Thr 179 | engineered mutation |
| Phe 182 | Tyr 181 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39854.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 470.0 | |
| All* | Total formula weight | 40324.6 |
