2CMB
Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidinone Heterocyclic Phosphonate Mimetics
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 1 | polymer | 304 | 35549.4 | 1 | UniProt (P18031) Pfam (PF00102) In PDB | HOMO SAPIENS (HUMAN) | PROTEIN-TYROSINE PHOSPHATASE 1B, PTP-1B |
2 | A | N-{[4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)PHENYL]ACETYL}-L-PHENYLALANYL-4-(1,1-DIOXIDO-3-OXO-2,3-DIHYDROISOTHIAZOL-5-YL)-L-PHENYLALANINAMIDE | non-polymer | 691.7 | 1 | Chemie (F17) | |||
3 | A | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
4 | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35549.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 984.1 | |
All* | Total formula weight | 36533.5 |