2AX0

Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5x)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Genome polyprotein	polymer	580	64638.1	2	UniProt (P26663) Pfam (PF00998) In PDB	Hepatitis C virus
2	A, B	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
3	A, B	5R-(2E-METHYL-3-PHENYL-ALLYL)-3-(BENZENESULFONYLAMINO)-4-OXO-2-THIONOTHIAZOLIDINE	non-polymer		418.6	2	Chemie (5X)
4		water	water		18.0	862	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: P26663)

PDB	External Database	Details
Ala 499	Val 2917	engineered mutation
Asn 506	Ser 2924	engineered mutation
Arg 514	Gln 2932	engineered mutation
Ile 520	Thr 2938	engineered mutation
Ala 540	Pro 2958	engineered mutation
Gly 543	Ser 2961	engineered mutation
Ser 549	Gly 2967	engineered mutation
Thr 552	Val 2970	engineered mutation
Gly 563	Ser 2981	engineered mutation
Val 564	Leu 2982	engineered mutation
His 566	Arg 2984	engineered mutation
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag
His 577	-	expression tag
His 578	-	expression tag
His 579	-	expression tag
His 580	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	129276.1
Non-Polymers*	Number of molecules	9
	Total formula weight	1509.5
All*	Total formula weight	130785.7

*Water molecules are not included.