1X0N
NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Growth factor receptor-bound protein 2 | polymer | 104 | 12012.5 | 1 | UniProt (P62993) Pfam (PF00017) In PDB | Homo sapiens (human) | GRB2, GRB2 adapter protein, SH2/SH3 adapter GRB2, Ash protein |
| 2 | A | 4-[(10S,14S,18S)-18-(2-AMINO-2-OXOETHYL)-14-(1-NAPHTHYLMETHYL)-8,17,20-TRIOXO-7,16,19-TRIAZASPIRO[5.14]ICOS-11-EN-10-YL]BENZYLPHOSPHONIC ACID | non-polymer | 688.8 | 1 | Chemie (DTF) |
Sequence modifications
A: 58 - 159 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| Gly 56 | - | cloning artifact |
| Ser 57 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 12012.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 688.8 | |
| All* | Total formula weight | 12701.3 |
