1T45

STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	polymer	331	37669.6	1	UniProt (P10721) GenBank (4557695) Pfam (PF07714) In PDB	Homo sapiens (human)	KIT
2		water	water		18.0	166	Chemie (HOH)

Sequence modifications

A: 547 - 693 (UniProt: P10721)

PDB	External Database	Details
Thr 694	-	see remark 999
Ser 753	-	see remark 999

A: 754 - 935 (GenBank: 4557695)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37669.6
All*	Total formula weight	37669.6

*Water molecules are not included.