1SV5

CRYSTAL STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R165335

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse Transcriptase	polymer	560	64485.9	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus 1	HIV-1 RT
2	B	Reverse Transcriptase	polymer	430	50266.7	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus 1	HIV-1 RT
3	A	4-({6-AMINO-5-BROMO-2-[(4-CYANOPHENYL)AMINO]PYRIMIDIN-4-YL}OXY)-3,5-DIMETHYLBENZONITRILE	non-polymer		435.3	1	Chemie (65B)

Sequence modifications

A: 1 - 560 (UniProt: P03366)

PDB	External Database	Details
Asn 103	Lys 270	engineered mutation
Ser 280	Cys 447	engineered mutation

B: 1 - 430 (UniProt: P03366)

PDB	External Database	Details
Asn 103	Lys 270	engineered mutation
Ser 280	Cys 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114752.6
Non-Polymers*	Number of molecules	1
	Total formula weight	435.3
All*	Total formula weight	115187.8

*Water molecules are not included.