1S64

Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I...	Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit	polymer	377	44098.1	6	UniProt (Q04631) Pfam (PF01239) In PDB	Rattus norvegicus (Norway rat)	CAAX farnesyltransferase alpha subunit, Ras proteins prenyltransferase alpha, FTase-alpha, Type I protein geranyl-geranyltransferase alpha subunit, GGTase-I-alpha
2	B, D, F, H, J...	Geranylgeranyl transferase type I beta subunit	polymer	377	42466.2	6	UniProt (P53610) Pfam (PF00432) In PDB	Rattus norvegicus (Norway rat)	Type I protein geranyl-geranyltransferase beta subunit, GGTase-I-beta
3	H, J, B, L, D...	ZINC ION	non-polymer		65.4	6	Chemie (ZN)
4	H, J, B, L, D...	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
5	H, J, B, L, D...	4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE	non-polymer		405.9	6	Chemie (778)
6	F, H, J, B, L...	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	6	Chemie (MES)
7	G, H, I, J, K...	CHLORIDE ION	non-polymer		35.5	9	Chemie (CL)
8		water	water		18.0	1375	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	519385.9
Non-Polymers*	Number of molecules	33
	Total formula weight	4894.6
All*	Total formula weight	524280.5

*Water molecules are not included.