1RD4
An allosteric inhibitor of LFA-1 bound to its I-domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Integrin alpha-L | polymer | 191 | 21669.9 | 4 | UniProt (P20701) Pfam (PF00092) In PDB | Homo sapiens (human) | Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function associated molecule 1 alpha chain, CD11a |
| 2 | A, B, C, D | 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE | non-polymer | 478.6 | 4 | Chemie (L08) |
Sequence modifications
A, B, C, D: 125 - 311 (UniProt: P20701)
| PDB | External Database | Details |
|---|---|---|
| Gly 121 | - | cloning artifact |
| Ala 122 | - | cloning artifact |
| Met 123 | - | cloning artifact |
| Ser 124 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86679.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1914.3 | |
| All* | Total formula weight | 88593.8 |
