1QE1

CRYSTAL STRUCTURE OF 3TC-RESISTANT M184I MUTANT OF HIV-1 REVERSE TRANSCRIPTASE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	REVERSE TRANSCRIPTASE, SUBUNIT P66	polymer	558	64256.6	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 BH10	RT
2	B	REVERSE TRANSCRIPTASE, SUBUNIT P51	polymer	427	49893.3	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 BH10	RT

Sequence modifications

A: 1 - 558 (UniProt: P03366)

PDB	External Database	Details
Ile 184	Met 351	engineered mutation
Ser 280	Cys 447	engineered mutation

B: 1 - 427 (UniProt: P03366)

PDB	External Database	Details
Ile 184	Met 351	engineered mutation
Ser 280	Cys 447	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	114149.9
All*	Total formula weight	114149.9

*Water molecules are not included.