1P18

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, ternary substrates complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	hypoxanthine phosphoribosyltransferase	polymer	221	25623.4	2	UniProt (Q27796) Pfam (PF00156) UniProt (by SIFTS) (Q4DRC4) In PDB	Trypanosoma cruzi
2	A, B	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
3	A, B	7-HYDROXY-PYRAZOLO[4,3-D]PYRIMIDINE	non-polymer		136.1	2	Chemie (7HP)
4	A, B	1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose	non-polymer		390.1	2	Chemie (PRP)
5		water	water		18.0	109	Chemie (HOH)

Sequence modifications

A, B: 1 - 221 (UniProt: Q27796)

PDB	External Database	Details
Lys 23	Met 23	SEE REMARK 999
Arg 52	Lys 52	engineered mutation
Cys 66	Ser 66	SEE REMARK 999
Leu 86	Val 86	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51246.8
Non-Polymers*	Number of molecules	8
	Total formula weight	1149.6
All*	Total formula weight	52396.4

*Water molecules are not included.