1NWL
Crystal structure of the PTP1B complexed with SP7343-SP7964, a pTyr mimetic
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | protein-tyrosine phosphatase, non-receptor type 1 | polymer | 298 | 34646.4 | 1 | UniProt (P18031) Pfam (PF00102) In PDB | Homo sapiens (human) | PTP-1B; Protein-tyrosine phosphatase 1B; protein tyrosine phosphatase, placental |
| 2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | A | 3-(4-{2-[2-(2-BROMO-ACETYLAMINO)-ETHYLDISULFANYL]-ETHYLCARBAMOYL}-CYCLOHEXYLCARBAMOYL)-PYRAZINE-2-CARBOXYLIC ACID | non-polymer | 469.6 | 1 | Chemie (964) | |||
| 4 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P18031)
| PDB | External Database | Details |
|---|---|---|
| Ser 32 | Cys 32 | engineered mutation |
| Cys 47 | Arg 47 | engineered mutation |
| Val 92 | Cys 92 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34646.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 493.9 | |
| All* | Total formula weight | 35140.3 |
