1M17
Epidermal Growth Factor Receptor tyrosine kinase domain with 4-anilinoquinazoline inhibitor erlotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | epidermal growth factor receptor | polymer | 333 | 37875.8 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (human) | Receptor protein-tyrosine kinase ErbB-1 |
| 2 | A | [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE | non-polymer | 393.4 | 1 | Chemie (AQ4) | |||
| 3 | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 671 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 666 | - | cloning artifact |
| Ser 667 | - | cloning artifact |
| His 668 | - | cloning artifact |
| Met 669 | - | cloning artifact |
| Ala 670 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37875.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 393.4 | |
| All* | Total formula weight | 38269.2 |
