1LQF

Structure of PTP1b in Complex with a Peptidic Bisphosphonate Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	protein-tyrosine phosphatase, non-receptor type 1	polymer	295	34451.4	4	UniProt (P18031) Pfam (PF00102) In PDB	Homo sapiens (human)	PTP1B, Protein Tyrosine Phosphatase 1B
2	A, B, C, D	N-BENZOYL-L-GLUTAMYL-[4-PHOSPHONO(DIFLUOROMETHYL)]-L-PHENYLALANINE-[4-PHOSPHONO(DIFLUORO-METHYL)]-L-PHENYLALANINEAMIDE	non-polymer		804.6	4	Chemie (BGD)
3		water	water		18.0	528	Chemie (HOH)

Sequence modifications

A, B, C, D: 501 - 783 (UniProt: P18031)

PDB	External Database	Details
Met 489	-	see remark 999
Asp 490	-	see remark 999
Tyr 491	-	see remark 999
Lys 492	-	see remark 999
Asp 493	-	see remark 999
Asp 494	-	see remark 999
Asp 495	-	see remark 999
Asp 496	-	see remark 999
Lys 497	-	see remark 999
Leu 498	-	see remark 999
Glu 499	-	see remark 999
Phe 500	-	see remark 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	137805.5
Non-Polymers*	Number of molecules	4
	Total formula weight	3218.3
All*	Total formula weight	141023.8

*Water molecules are not included.