1K2D

Crystal structure of the autoimmune MHC class II I-Au complexed with myelin basic protein 1-11 at 2.2A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	H-2 class II histocompatibility antigen, A-U alpha chain	polymer	189	21468.8	1	UniProt (P14438) Pfam (PF00993) Pfam (PF07654) In PDB	Mus musculus (house mouse)	MHC CLASS II I-AU
2	B	H-2 class II histocompatibility antigen, A-U beta chain	polymer	189	22495.2	1	UniProt (P06344) Pfam (PF00969) Pfam (PF07654) In PDB	Mus musculus (house mouse)	MHC CLASS II I-AU
3	P	Myelin Basic Protein peptide with 8 residue linker peptide	polymer	23	2319.4	1	GenBank (14763906) UniProt (by SIFTS) (P02686) In PDB		MBP peptide
4	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5		water	water		18.0	450	Chemie (HOH)

Sequence modifications

A: 4 - 181 (UniProt: P14438)

PDB	External Database	Details
His -6	-	cloning artifact
Ser -5	-	cloning artifact
Arg -4	-	cloning artifact
Gly -3	-	cloning artifact
Glu -2	-	cloning artifact
Asp -1	-	cloning artifact
Asp 0	-	cloning artifact
Ile 1	-	cloning artifact
Glu 2	-	cloning artifact
Ala 3	-	cloning artifact

P: 0 - 10 (GenBank: 14763906)

PDB	External Database	Details
His -4	-	cloning artifact
Ser -3	-	cloning artifact
Arg -2	-	cloning artifact
Gly -1	-	cloning artifact
Gly 0	Met 1	conflict
Gly 11	-	linker
Thr 12	-	linker
Gly 13	-	linker
Ser 14	-	linker
Gly 15	-	linker
Ser 16	-	linker
Gly 17	-	linker
Ser 18	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	46283.4
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	46947.0

*Water molecules are not included.