1ISO
ISOCITRATE DEHYDROGENASE: STRUCTURE OF AN ENGINEERED NADP+--> NAD+ SPECIFICITY-REVERSAL MUTANT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ISOCITRATE DEHYDROGENASE | polymer | 416 | 45701.4 | 1 | UniProt (P08200) Pfam (PF00180) In PDB | Escherichia coli | OXALOSUCCINATE DECARBOXYLASE, IDH |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | A | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 4 | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A: 1 - 416 (UniProt: P08200)
| PDB | External Database | Details |
|---|---|---|
| Met 201 | Cys 201 | engineered mutation |
| Tyr 332 | Cys 332 | engineered mutation |
| Asp 344 | Lys 344 | engineered mutation |
| Ile 345 | Tyr 345 | engineered mutation |
| Ala 351 | Val 351 | engineered mutation |
| Lys 391 | Tyr 391 | engineered mutation |
| Ser 395 | Arg 395 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45701.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 951.6 | |
| All* | Total formula weight | 46653.0 |
