1I8K
CRYSTAL STRUCTURE OF DSFV MR1 IN COMPLEX WITH THE PEPTIDE ANTIGEN OF THE MUTANT EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII, AT LIQUID NITROGEN TEMPERATURE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY MR1SCFV LIGHT CHAIN | polymer | 107 | 11745.0 | 1 | UniProt (Q8R028) Pfam (PF07686) UniProt (by SIFTS) (P01660) In PDB | Mus musculus (house mouse) | DSFV MR1 VARIABLE DOMAIN LIGHT CHAIN |
| 2 | B | EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY MR1SCFV HEAVY CHAIN | polymer | 124 | 13712.4 | 1 | UniProt (P18529) Pfam (PF07686) In PDB | Mus musculus (house mouse) | DSFV MR1 VARIABLE DOMAIN HEAVY CHAIN |
| 3 | C | EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN | polymer | 12 | 1421.5 | 1 | EPIDERMAL GROWTH FACTOR RECEPTOR, EGFRVIII PEPTIDE ANTIGEN | ||
| 4 | water | water | 18.0 | 260 | Chemie (HOH) |
Sequence modifications
A: 1 - 107 (UniProt: Q8R028)
B: 301 - 424 (UniProt: P18529)
| PDB | External Database | Details |
|---|---|---|
| Cys 100 | Asp 235 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 344 | Arg 44 | engineered mutation |
| Gly 420 | Ser 120 | conflict |
| Ile 421 | Ser 121 | conflict |
| Glu 422 | Gly 122 | conflict |
| Arg 424 | Gly 124 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 26878.9 | |
| All* | Total formula weight | 26878.9 |
