1E9D

Mutant human thymidylate kinase (F105Y) complexed with AZTMP and ADP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	THYMIDYLATE KINASE	polymer	215	24140.7	1	UniProt (P23919) Pfam (PF02223) In PDB	HOMO SAPIENS (HUMAN)	DTMP KINASE
2	A	3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE	non-polymer		347.2	1	Chemie (ATM)
3	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
4	A	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5		water	water		18.0	199	Chemie (HOH)

Sequence modifications

A: -3 - -1 (PDB: 1E9D)
A: 1 - 212 (UniProt: P23919)

PDB	External Database	Details
Ala 200	Arg 200	engineered mutation
Tyr 105	Phe 105	engineered mutation
Ile 184	Leu 184	conflict
Ile 191	Leu 191	conflict
Lys 208	Gly 208	conflict
Asp 190	Glu 190	conflict
Ser 183	Arg 183	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	24140.7
Non-Polymers*	Number of molecules	4
	Total formula weight	823.0
All*	Total formula weight	24963.7

*Water molecules are not included.